Prozac and related drugs can cause a manic condition of physical and mental agitation. About 1 in 16 people who use these drugs report this side effect. Far more people experience nervousness, restlessness, anxiety, and uncharacteristic aggressiveness. Another side effect associated with these antidepressants is increased thoughts of suicide. Dr. David Healy published a study in 200 showing that when people with no mental illness or prior history of depression were administered the drug Zoloft, 20 percent became suicidal! This class of drugs also increased the tendency towards self-harm. So my suggestion is, if you're taking these drugs, let a friend know so they can give you feedback on your behavior.